Katia Basso, PhD

Associate Professor of Pathology and Cell Biology (in the Institute for Cancer Genetics)

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The germinal center contains multiple cell populations.

Katia Basso studies the process of differentiation of germinal center B cells and the mechanisms of malignant transformation leading to lymphomagenesis. Her interest is in dissecting the transcriptional networks that drive normal B cell differentiation and are hijacked in lymphomas. She integrates omics technologies, molecular and cellular biology, and in-vivo modeling to characterize normal B cells and their malignant counterparts. Her research informs on lymphoma features and dependences that impact diagnostics and therapeutics.

Selected Publications

1
Tracking Immunoglobulin Repertoire and Transcriptomic Changes in Germinal Center B Cells by Single-Cell Analysis

Corinaldesi C, Holmes AB, Shen Q, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K

Front Immunol. 2021.

PMID: 35095922
2
Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome

Holmes AB, Corinaldesi C, Shen Q, Kumar R, Compagno N, Wang Z, Nitzan M, Grunstein E, Pasqualucci L, Dalla-Favera R, Basso K

J Exp Med. 2020.

PMID: 32603407
3
MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis

Brescia P, Schneider C, Holmes AB, Shen Q, Hussein S, Pasqualucci L, Basso K, Dalla-Favera R

Cancer Cell. 2018.

PMID: 30205047
4
FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease

Schneider C, Kon N, Amadori L, Shen Q, Schwartz FH, Tischler B, Bossennec M, Dominguez-Sola D, Bhagat G, Gu W, Basso K, Dalla-Favera R

Blood. 2016.

PMID: 27166359
5
Germinal centres and B cell lymphomagenesis

Basso K, Dalla-Favera R

Nat Rev Immunol. 2015.

PMID: 25712152
6
The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program

Dominguez-Sola D, Kung J, Holmes AB, Wells VA, Mo T, Basso K, Dalla-Favera R

Immunity. 2015.

PMID: 26620759
7
MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas

Schneider C, Setty M, Holmes AB, Maute RL, Leslie CS, Mussolin L, Rosolen A, Dalla-Favera R, Basso K

Proc Natl Acad Sci USA. 2014.

PMID: 24843176
8
tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

Maute RL, Schneider C, Sumazin P, Holmes A, Califano A, Basso K, Dalla-Favera R

Proc Natl Acad Sci USA. 2013.

PMID: 23297232
9
MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma

Ying CY, Dominguez-Sola D, Fabi M, Lorenz IC, Hussein S, Bansal M, Califano A, Pasqualucci L, Basso K, Dalla-Favera R

Nat Immunol. 2013.

PMID: 23974956
10
Roles of BCL6 in normal and transformed germinal center B cells

Basso K, Dalla-Favera R

Immunol Rev. 2012.

PMID: 22500840
11
BCL6 positively regulates AID and germinal center gene expression via repression of miR-155

Basso K, Schneider C, Shen Q, Holmes AB, Setty M, Leslie C, Dalla-Favera R

J Exp Med. 2012.

PMID: 23166356
12
Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells

Basso K, Saito M, Sumazin P, Margolin AA, Wang K, Lim WK, Kitagawa Y, Schneider C, Alvarez MJ, Califano A, Dalla-Favera R

Blood. 2010.

PMID: 19965633
13
Identification of the human mature B cell miRNome

Basso K, Sumazin P, Morozov P, Schneider C, Maute RL, Kitagawa Y, Mandelbaum J, Haddad J, Chen CZ, Califano A, Dalla-Favera R

Immunity. 2009.

PMID: 19446474
14
Toward a systems biology approach to investigate cellular networks in normal and malignant B cells

Basso K

Leukemia. 2009.

PMID: 19194469
15
Reverse engineering of regulatory networks in human B cells

Basso K, Margolin AA, Stolovitzky G, Klein U, Dalla-Favera R, Califano A

Nat Genet. 2005.

PMID: 15778709

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